I just ran across a pretty annoying issue when updating one of my TWiki's from 4.2.0 to 4.2.2. The server it is on was running Perl 5.10, but the Encode module was 2.25, resulting in Wysiwyg edits having all their spaces replaced with %20, and line feeds %0A ala
%20Debian%20equivalent%20of%20chkconfig%0A%0A/usr/sbin/update-rc.d%20avahi-daemon%20defaults%0A%0Ahttp%3A//wiki.linuxmce.org/index.php/Hardware%0A
(look familiar Martin? :))
perl -MCPAN -e shell
upgrade Encode
Got me to Encode v2.26, which fixed it for me.
update: Martin's just confirmed that it didn't help him on perl 5.8.4, so perhaps its an odd combination of outdated modules?